|
KMID : 0363819750090010045
|
|
Korean Journal of Nuclear Medicine
1975 Volume.9 No. 1 p.45 ~ p.50
|
|
|
A Clinical Study on the Shape of Normal Liver by Scintiphoto
|
|
張高昌/Chang, Kochang
朴鍾仁/金鍾卨/李眞悟/李章圭/Park, Jong In/Kim, Chong Suhl/Lee, Jin Oh/Lee, Jang Kyu
|
|
|
Abstract
|
|
|
53 patients with hyperthyroidism have been analyzed with special reference to therapeutic
response to radioactive iodine (1311) treatment.
Mean effective half-life, ~,24,hour uptake rate and radiation dose of 1411 in hyperthyroid patients included in this study were respectively
1. Mean effective half-life of 1311 was 4. 7±1. 5 days in the tracer dose and 5.0±1.5 days in the therapeutic dose.
2. Mean 24 hour uptake rate of 1311 was 72.7±11.1% in the tracer dose and 73.4±12.3% in the theapeutic dose.
3. Mean radiation dose of 1311 was 5, 319±2, 648 RAD as predicted and 5, 692±2, 843 RAD as actual.
A single dose of radioactive iodine treatment was satisfactory in 34 patients (radioiodine sensitive) and multiple doses of radioactive iodine treatments were required in 19 patients (radioiodine resistant).
A radioiodine resistant group of patients with hyperthyroidism was distinctively characteristic in the following aspects.
1. Mean thyroid weight calculated in the resistant group (63.9±14.0 gm) was significantly (P<0.01) greater than that of the sensitive group (46.6±13.3 gm).
2. Mean 24 hour uptake rate of the tracer dose in the resistant group (67.3±10.7%) was significantly (p<0.01)_lower than that of the sensitive group (75.7±10.5%).
3. Mean 24 hour uptake rate of the therapeutic dose in the resistant group (68.5±13.7%) was significantly (p<0. 05) lower than that of the sensitive group (76.1±10. 9%).
4. Mean predicted radiation- dose, of 1311 in the resistant group (3,684±1,745 RAD) was significantly (p<0. 01) lower than that of the sensitive group (6, 232±2, 683 RAD).
5. Mean actual radiation dose of 1311 in the resistant group (4,100±1,691 RAD) was significantly (p<0.01) lower than that of the sensitive group (6, 582±3,024 RAD).
6. No significant difference was detected in terms of effective half-life of 13´I among the groups (p>0.05).
7. The average mean % difference of effective half-life, uptake rate and radiation dose measured following the tracer and therapeutic dose of 1311 were not statistically significant (p>0.05). Therefore effective half-life, uptake rate and radiation dose of the therapeutic dose of 1311 were readily predictable following the tracer dose of 1311.
8. It is concluded that the possibility of resistance to radioactive iodine treatment may be anticipated in patients with thyroid gland large in size and compromised 131I uptake rate.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|